Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation

نویسندگان
چکیده

منابع مشابه

Transcription-dependent redistribution of nuclear protein 4.1 to SC35-enriched nuclear domains.

Protein 4.1, originally identified as a component of the membrane-skeleton of the red blood cell, has also been localized in the nucleus of mammalian cells. To learn more about nuclear 4.1 protein, we have analyzed the nature of its association with the nuclear structure in comparison with SC35 and snRNP antigens, splicing proteins of the nuclear speckle domains. When MDCK or HeLa cells were di...

متن کامل

Charge fluctuations and counterion condensation.

We predict a condensation phenomenon in an overall neutral system, consisting of a single charged plate and its oppositely charged counterions. Based on the "two-fluid" model, in which the counterions are divided into a "free" and a "condensed" fraction, we argue that for high surface charge, fluctuations can lead to a phase transition in which a large fraction of counterions is condensed. Furt...

متن کامل

Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis.

The linear distribution of genes across chromosomes and the spatial localization of genes within the nucleus are related to their transcriptional regulation. The mechanistic consequences of linear gene order, and how it may relate to the functional output of genome organization, remain to be fully resolved, however. Here we tested the relationship between linear and 3D organization of gene regu...

متن کامل

Nuclear-Charge Screening in Positronium Formation from Helium Atoms

An analytical treatment of the electron screening effect within an active-electron model is given for positronium formation from helium atoms. A first-order distorted wave approximation with correct boundary conditions is applied to evaluate the transition amplitude. In the range of impact energy for which the introduced perturbative approach is valid, both the total and differential cross sect...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Molecular Cell

سال: 2020

ISSN: 1097-2765

DOI: 10.1016/j.molcel.2020.01.025